Splenic uptake of both technetium-99m diphosphonate and technetium-99m sulfur colloid in sickle cell beta degrees thalassemia

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Clinical Nuclear Medicine; (USA)

DOI:https://doi.org/10.1097/00003072-198908000-00001· OSTI ID:5128822

Heck, L L; Brittin, G M ^[1]

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1. Methodist Hospital of Indiana, IN (USA)

A 19-year-old black woman with sickle cell beta degrees thalassemia had experienced more than 100 hospital admissions for sickle cell crisis and aseptic necrosis of both femoral heads. Her spleen was enlarged threefold and accumulated both radiocolloid and bone-seeking agent on two occasions, demonstrating an exception to the rule in sickle cell anemia that spleens that take up bone-seeking agents demonstrate functional asplenia. In the context of fever, left upper quadrant pain, and splenomegaly, the pattern of calcification in the patient's spleen as revealed in ultrasound and CT studies suggested possible abscess and led to unnecessary splenectomy. The nuclear medicine studies did not support this diagnosis. Nuclear medicine physicians should not be misled by splenic findings of sickle cell thalassemia (and possibly of other heterozygous sickle cell disorders) that differ from those of the more familiar homozygous sickle cell anemia.

• OSTI ID: 5128822
• Journal Information: Clinical Nuclear Medicine; (USA), Vol. 14:8; ISSN 0363-9762
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
SICKLE CELL ANEMIA
DIAGNOSIS
SPLEEN
RADIONUCLIDE KINETICS
TECHNETIUM 99
UPTAKE
COLLOIDS
COMPUTERIZED TOMOGRAPHY
ULTRASONOGRAPHY
ANEMIAS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SYMPTOMS
TECHNETIUM ISOTOPES
TOMOGRAPHY
YEARS LIVING RADIOISOTOPES
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man
550601 - Medicine- Unsealed Radionuclides in Diagnostics