Reaction of cyanide with Pt-nucleobase complexes: preparative, spectroscopic, and structural studies. Unexpected stability of Pt-thymine and Pt-uracil complexes
In order to improve the understanding of the nature of the strongly bound cisplatin on DNA, the reactivity of a large number of complexes of cis-(NH/sub 3/)/sub 2/Pt/sup II/ with the model nucleobases, 9-ethylguanine, 9-methyladenine, 1-methylcytisine, 1-methylthymine, and i-methyluracil, toward a large excess of cyanide was studied. The behavior of Pt-nucleobase complexes toward CN/sup -/ is compared with that of simple Pt-amine complexes, and reactions of thiourea with two selected nucleobase complexes is reported. The relevance of these findings with respect to substitution reactions of Pt-nucleobase complexes and the nature of the tightly DNA-bound Pt, which cannot be removed by excess KCN, is discussed.
- Research Organization:
- Technische Universitaet Muenchen, Garching, West Germany
- OSTI ID:
- 5126959
- Journal Information:
- Inorg. Chem.; (United States), Vol. 24:15
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
AMINES
CHEMICAL REACTIONS
AMMONIA
CYANIDES
DEUTERIUM
ISOTOPE EFFECTS
DNA
ORGANOMETALLIC COMPOUNDS
PLATINUM COMPLEXES
COMPLEXES
HYDRIDES
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
ISOTOPES
LIGHT NUCLEI
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
STABLE ISOTOPES
TRANSITION ELEMENT COMPLEXES
550600* - Medicine
400301 - Organic Chemistry- Chemical & Physicochemical Properties- (-1987)
400302 - Organic Chemistry- Isotope Effects- (-1987)
400201 - Chemical & Physicochemical Properties