Rat parotid cell function in vitro following x irradiation in vivo
The effect of X irradiation on rat parotid acinar cell function was evaluated in vitro 1, 3, and 7 days following in vivo exposure to 2000 R. Several cellular functions were followed: protein secretion (amylase release), ion movement (K/sup +/ efflux and reuptake), amino acid transport (..cap alpha..-amino(/sup 14/C)isobutyric acid), and an intermediary metabolic response ((/sup 14/C)glucose oxidation). In addition both the morphologic appearance and in vivo saliva secretory ability of parotid cells were assessed. Our results demonstrate that surviving rat parotid acinar cells, isolated and studied in vitro 1-7 days following 2000 R, remain functionally intact despite in vivo diminution of secretory function.
- Research Organization:
- National Inst. of Health, Bethesda, MD
- OSTI ID:
- 5126248
- Journal Information:
- Radiat. Res.; (United States), Vol. 97:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of 5-fluorouracil on the secretory process of the rat parotid gland
CONSIDERATIONS ON THE HISTOCHEMICAL AND HISTOLOGICAL MODIFICATIONS INDUCED BY IONIZING RADIATIONS IN PAROTID CELLS OF EPIMYS NORVEGICUS VAR, ALBINA ERXL
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
SALIVARY GLANDS
BIOLOGICAL RADIATION EFFECTS
AMYLASE
ANIMAL CELLS
CARBON 14 COMPOUNDS
EXPERIMENTAL DATA
GLUCOSE
IN VITRO
IN VIVO
IONS
MEMBRANE TRANSPORT
OXIDATION
RATS
X RADIATION
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
CHARGED PARTICLES
CHEMICAL REACTIONS
DATA
ELECTROMAGNETIC RADIATION
ENZYMES
GLANDS
GLYCOSYL HYDROLASES
HEXOSES
HYDROLASES
INFORMATION
IONIZING RADIATIONS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NUMERICAL DATA
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SACCHARIDES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550201 - Biochemistry- Tracer Techniques