Protection from radiation nephropathy by WR-2721

Journal Article · Wed Feb 01 00:00:00 EST 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576292· OSTI ID:5126241

Donaldson, S S ^[1]; Moskowitz, P S; Evans, J W; Fajardo, L F

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1. Stanford Univ. School of Medicine, CA

The efficacy of WR-2721 pretreatment against radiation injury to the growing kidney was evaluated in the weanling mouse. Immediately following unilateral nephrectomy, animals received intraperitoneal injections of saline or WR-2721 (220 mg/kg). Thirty minutes later both nonprotected (saline-treated) control animals and protected (WR-2721-treated) animals received 1000-rad single-fraction radiation to the remaining kidney. Other animals received WR-2721 immediately following unilateral nephrectomy but no radiation. Animals were sacrificed at 3 and 24 weeks. Nonirradiated animals treated with WR-2721 only showed normal compensatory renal growth, body growth, and renal function at 24 weeks. The nonprotected, irradiated animals exhibited renal growth inhibition without body growth inhibition, and renal functional abnormalities including elevation of serum BUN and reduction of glomerular filtration rate. Pretreatment with WR-2721 prior to 1000 rad prevented the renal growth inhibition and functional abnormalities seen in the nonprotected irradiated animals. Within the observation period there were no differences in renal morphology by light and electron microscopy between protected and nonprotected groups; only mild glomerular and tubular abnormalities compatible with radiation injury were seen. The dose reduction factor for WR-2721 renal growth protection is between 1.16 and 1.2.

• OSTI ID: 5126241
• Journal Information: Radiat. Res.; (United States), Vol. 97:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ATROPHY
RADIOINDUCTION
FIBROSIS
KIDNEYS
BIOLOGICAL RADIATION EFFECTS
THIOIC ACIDS
RADIOSENSITIVITY EFFECTS
MICE
NEPHRECTOMY
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RODENTS
SURGERY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550900 - Pathology