Effect of dose level and pregnancy on the distribution and toxicity of intravenous lead in rats
Female Wistar rats were injected intravenously with tracer levels of /sup 210/Pb, alone or combined with carrier Pb(NO/sub 3/)/sub 2/ at 5 or 25 mg/kg body weight at 9 or 15 days of gestation (dg). Tissue /sup 210/Pb distribution and retention, and lead excretion, were measured several times during the first 30 h and at 20 dg. Toxic effects following the administration of 25 mg/kg (a tertogenic dose) included an early decrease in hematocrit, hematuria, gastrointestinal hemorrhage, and diarrhea, as well as an eventual body weight and an increase in spleen and kidney weights. The stage of pregnancy at injection did not affect the retention and distribution of lead in major organs other than the reproductive system. Following injection of the 25-mg/kg dose, deposition of lead in the liver, kidney, spleen, and lung was elevated. Disproportionately high plasma lead levels were also observed at early times after the injection of the 25-mg/kg dose, and may act as a significant factor in placental lead transfer and subsequent malformations or fetal mortality.
- Research Organization:
- Pacific Northwest Lab., Richland, WA
- OSTI ID:
- 5125745
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 9:5-6
- Country of Publication:
- United States
- Language:
- English
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Distribution and effects of intravenous lead in the fetoplacental unit of the rat
Distribution and effects of intravenous lead in the fetoplacental unit of the rat
Related Subjects
LEAD
BIOLOGICAL EFFECTS
RETENTION
TISSUE DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
HEMORRHAGE
INTRAVENOUS INJECTION
LABELLED COMPOUNDS
LEAD 210
PLACENTA
PREGNANCY
RATS
WEIGHT
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DISTRIBUTION
ELEMENTS
EVEN-EVEN NUCLEI
FETAL MEMBRANES
HEAVY NUCLEI
INJECTION
INTAKE
ISOTOPES
LEAD ISOTOPES
MAMMALS
MEMBRANES
METALS
NUCLEI
PATHOLOGICAL CHANGES
RADIOISOTOPES
RODENTS
SYMPTOMS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)