Effect of imidazole and indomethacin on hemodynamics of the obstructed canine kidney
In the anesthetized dog renal blood flow (RBF) and its intrarenal distribution were investigated by the radioactive microsphere technique 24 hr after bilateral (BUL) and unilateral (UUL) ureteral ligation. In the control series indomethacin (IM) led to a decrease in RBF with outward shifting of zonal perfusions; imidazole (IA) did not cause significant changes in renal hemodynamics. In the BUL series there was a sharp drop in RBF with a proportional decrease in outer (OC) and inner (IC) cortical perfusion; IM treatment resulted in a further decrease in overall and zonal perfusions. IA, a selective inhibitor of thromboxane synthetase, relieved IC vasoconstriction. In the ligated kidney of the UUL preparations decrease in RBF was due to OC vasoconstriction, while IC perfusion equalled controls. IM led to an overall vasoconstriction in all cortical layers; IA did not influence either total RBF or its distribution. It was concluded that BUL ''unmasked'' TXA2 production in the IC layers, while IM treatment, by inhibiting the production of PGE2, PGI2, and TXA2, resulted in an overall vasoconstriction both in controls and the BUL and UUL preparations.
- Research Organization:
- Semmelweis Univ. Medical School, Budapest, Hungary
- OSTI ID:
- 5119081
- Journal Information:
- Kidney Int.; (United States), Vol. 6
- Country of Publication:
- United States
- Language:
- English
Similar Records
Thromboxane-mediated injury following radiation. Annual summary report No. 1, January-September 1984
Hypersensitive prostaglandin and thromboxane response to hormones in rabbit colitis
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ANTIPYRETICS
BIOLOGICAL EFFECTS
IMIDAZOLES
KIDNEYS
BLOOD FLOW
BLOOD CIRCULATION
DOGS
ENZYME INHIBITORS
LIGASES
MICROSPHERES
PERFUSED ORGANS
RADIOISOTOPES
VASOCONSTRICTION
VASODILATION
ANIMALS
AZOLES
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
ENZYMES
HETEROCYCLIC COMPOUNDS
ISOTOPES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551001 - Physiological Systems- Tracer Techniques