Dose-response toxicity studies on tributoxyethyl phosphate orally administered to Sprague-Dawley rats

Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668591395139· OSTI ID:5115681

Laham, S; Szabo, J; Long, G; Schrader, K

The response of the peripheral nervous system to various dose levels of tributoxyethyl phosphate (TBOP) was investigated in Sprague-Dawley rats. Groups of randomized female and male rats (10 rats/gender/dose level) were administered a single oral dose of TBOP (1.0 to 3.2 g/kg for females;1.0 to 9.0 g/kg for males). Physiological parameters were measured in surviving rats three weeks following TBOP administration. A significant reduction (p<0.05) in caudal nerve conduction velocity (NCV) was observed in both female and male rats. Light and electron microscopic examination of sciatic nerve sections showed degenerative changes in both myelinated and unmyelinated fibers of female (2.0 g/kg) and male (6.8 g/kg) groups. Advanced degeneration was observed only in the highest dose level of both genders (3.2 g/kg for females; 8.0 and 9.0 g/kg for males). Although similar morphological changes were observed in both genders, females were more susceptible than males to the toxic effects of this compound.

• Research Organization: Health and Welfare Canada, Ottawa, Ontario
• OSTI ID: 5115681
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Vol. 46:8
• Country of Publication: United States
• Language: English

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