Enhanced hematopoietic recovery in irradiated mice pretreated with interleukin-1 (IL-1)2,3

Technical Report · Thu Jan 01 00:00:00 EST 1987

OSTI ID:5102925

Schwartz, G N; MacVittie, T J; Vigneulle, R M; Patchen, M L; Douches, S D

Data in this report compare the number of colony-forming cells (CFC) in bone marrow from irradiated and pre-irradiated C57B1/6J mice injected with saline or recombinant interleukin-1-alpha (rIL-1). Eight to 12 days after sublethal or lethal irradiation, there were more CFU-E (colony-forming units-erythroid), BFU-E (burst-forming units erythroid), GM-CFC (granulocyte-macrophage colony-forming cells), and 8 CFU-S (colony-forming units-spleen) in bone marrow from rIL-1 injected mice than from saline injected mice. Prior to irradiation, there was no increase in number of CFC in bone marrow from rIL-1 injected mice. However, as determined by sensitivity to hydroxyurea, rIL-1 injection stimulated GM-CFC into cell cycle. These results demonstrate that rIL-1 injection increases the number of CFC that survive in irradiated mice and may be a consequence of the stimulation of CFC into cell cycle prior to irradiation.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
• OSTI ID: 5102925
• Report Number(s): AD-A-186543/5/XAB; AFRRI-SR-87-32
• Resource Relation: Other Information: Pub. in Immunopharmacology and Immunotoxicology, Vol. 9, No. 2/3, 371-389(1987)
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HEMATOPOIETIC SYSTEM
BIOLOGICAL RADIATION EFFECTS
BLOOD
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DISEASES
HYDROXYUREA
IRRADIATION
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560152* - Radiation Effects on Animals- Animals