Alveolar macrophage kinetics and function after interruption of canine marrow function

Journal Article · Mon Mar 01 00:00:00 EST 1982 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5102403

Springmeyer, S C; Altman, L C; Kopecky, K J; Deeg, H J; Storb, R

To study the kinetics and function of alveolar macrophages after interruption of marrow function, we performed serial bronchoalveolar lavages in dogs. The studies were performed before and after 9.0 to 9.5 Grey total body irradiation and marrow infusion. Monocytes had disappeared from the bloodstream by Day 7 after the irradiation. Alveolar macrophages were significantly decreased at Day 21. At Days 14 and 21 myeloperoxidase-positive alveolar macrophages were also significantly decreased. Beyond Day 30 the number of circulating monocytes, myeloperoxidase-positive and total alveolar macrophages had returned. Sex chromatin stains of alveolar macrophages obtained from a male dog that received female marrow indicated that the repopulating macrophages were of marrow origin. In vitro studies of alveolar macrophage migration and phagocytosis demonstrated increased activities beyond Day 30. These studies suggest that in this model the alveolar macrophage is dependent on the bone marrow for support and that the alveolar macrophage depletion may impair lung defense mechanisms.

• Research Organization: Department of Medicine and Biostatistics, University of Washington School of Medicine, Seattle
• OSTI ID: 5102403
• Journal Information: Am. Rev. Respir. Dis.; (United States), Vol. 125:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DOGS
WHOLE-BODY IRRADIATION
LEUKOPENIA
RADIOINDUCTION
MACROPHAGES
BIOLOGICAL RADIATION EFFECTS
KINETICS
POPULATION DYNAMICS
MONOCYTES
BONE MARROW
LUNGS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IRRADIATION
LEUKOCYTES
MAMMALS
MATERIALS
ORGANS
PHAGOCYTES
RADIATION EFFECTS
RESPIRATORY SYSTEM
SOMATIC CELLS
TISSUES
VERTEBRATES
560151* - Radiation Effects on Animals- Man
551000 - Physiological Systems