Effect of duct obstruction on structure, elemental composition, and function of rat submandibular glands

Journal Article · Thu Jun 01 00:00:00 EDT 1989 · Scanning Miscroscopy; (USA)

OSTI ID:5100675

Sagstroem, S S; Sagulin, G B; Roomans, G M ^[1]

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1. Univ. of Uppsala (Sweden)

Obstruction of salivary glands occurs in association with a number of pathological conditions. It has been suggested that the major changes found in the salivary glands of patients with cystic fibrosis are due to obstruction of the excretory duct by viscous mucus. In the present study, the effect of excretory duct obstruction on structure, elemental composition and function of rat submandibular gland was investigated. Obstruction was effected by infusion of a fast-hardening protein emulsion in the main excretory duct. After 1 week, and more pronounced after 2 weeks of obstruction the number of granular duct cells had decreased in the obstructed gland. X-ray microanalysis showed an increase in Mg, Ca and K, and a decrease in Na levels in the acinar cells, compared to normal glands. The contralateral glands apparently underwent compensatory hypertrophy and showed a similar pattern of changes in elemental composition. The composition of pilocarpine-induced submandibular saliva was neither in the obstructed nor in the contralateral gland significantly different from that in control glands. However, the flow rate was somewhat lower. Hence, increase in cellular Ca levels in submandibular gland acinar cells in cystic fibrosis could be secondary to duct obstruction, but the present study does not support the hypothesis that duct obstruction would result in changes in the composition of saliva.

• OSTI ID: 5100675
• Journal Information: Scanning Miscroscopy; (USA), Vol. 3:2; ISSN 0891-7035
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
RESPIRATORY SYSTEM DISEASES
PATHOGENESIS
SALIVARY GLANDS
PATHOLOGICAL CHANGES
CALCIUM COMPOUNDS
ELECTRON MICROPROBE ANALYSIS
HEREDITARY DISEASES
MAGNESIUM COMPOUNDS
PATIENTS
POTASSIUM COMPOUNDS
RATS
ALKALI METAL COMPOUNDS
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
BODY
CHEMICAL ANALYSIS
DISEASES
GLANDS
MAMMALS
MICROANALYSIS
ORGANS
RODENTS
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)