Radiation-induced emesis in monkeys

Journal Article · Tue Apr 01 00:00:00 EST 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575247· OSTI ID:5099603

Mattsson, J L; Yochmowitz, M G

To determine the emesis ED/sub 50/ for /sup 60/Co radiation, 15 male rhesus monkeys were exposed to whole-body radiation doses ranging from 350 to 550 rad midline tissue dose. An up-and-down sequence of exposures was used. Step size between doses was 50 rad, and dose rate was 20 rad/min. There had been no access to food for 1 to 2 h. The ED/sub 50/ +- SE was found to be 446 +- 27 rad. To determine the effect of motion on emesis ED/sub 50/, six more monkeys were exposed to /sup 60/Co radiation as above, except that the chair in which they were seated was oscillated forward and backward 5 to 15/sup 0/ (pitch axis) at a variable rate not exceeding 0.3 Hz. Radioemesis ED/sub 50/ +- SE with motion was 258 +- 19 rad, a value significantly lower (P < 0.01) than for stationary monkeys.

• Research Organization: USAF School of Aerospace Medicine, Brooks Air Force Base, TX
• OSTI ID: 5099603
• Journal Information: Radiat. Res.; (United States), Vol. 82:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MACACUS
BIOLOGICAL RADIATION EFFECTS
MOTION
RADIOSENSITIVITY EFFECTS
VOMITING
RADIOINDUCTION
COBALT 60
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
FASTING
GASTROINTESTINAL TRACT
NAUSEA
RADIATION DOSES
WHOLE-BODY IRRADIATION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
COBALT ISOTOPES
DIGESTIVE SYSTEM
DOSES
EXTERNAL IRRADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONKEYS
NUCLEI
ODD-ODD NUCLEI
PRIMATES
RADIATION EFFECTS
RADIOISOTOPES
SYMPTOMS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560151* - Radiation Effects on Animals- Man