Distribution and retention of hexavalent /sup 233/U in the beagle
The distribution, retention, and excretion of /sup 233/U were measured in seven beagles injected intravenously with 2.8 ..mu..Ci /sup 233/U(VI)/kg (approx. 3 mg/dog) in citrate buffer and sacrificed at times ranging from 1 to 726 days postinjection (PI). The concentration of U in plasma decreased rapidly, and for the first 24 h PI could be described by triphasic exponential equation with half-times of 0.92, 46, and 315 min. The uranium in the blood at 5 min PI was present as either a protein (transferrin-albumin) or a carbonate/bicarbonate complex. Up to 60% of the injected U was excreted during the first day, most of it in the urine. Whole-body retention was 17% at 7 days, 10% at 94 days, 7.6% at 1 year, and less than 5% at 2 years PI. Except for the kidney, only a small fraction of the injected U was retained in soft tissues. At 1 day PI, the liver contained 1.1% of the injected U and its subcellular distribution was similar to that seen with Pu(IV). At 1 day PI, 7.7% of the U was found in the skeleton; this amount decreased with a biological half-life of 883 days. Initially, U was deposited nonuniformly on bone surfaces with areas of intense hot spots adjacent to areas with intermediate and low concentrations. At later times redistribution and/or diffusion of U into the bone volume produced a deposition pattern intermediate to that of /sup 239/Pu (surface) and /sup 226/Ra (volume). The heterogeneit of surface deposits persisted, and isolated segments of the trabecular bone showed intense surface deposits at times greater than 1 year PI. Twnety-two percent of the injected U was found in the kidneys at 1 day PI with high concentrations localized in the proximal tubules. The initially high concentration of U in this organ was correlated with extensive diuresis and a persistent elevation in blood urea nitrogen. Damage to proximal tubules was attributed primarily to chemical toxicity but was aggravated by simultaneous ..cap alpha.. irradiation.
- Research Organization:
- Univ. of Utah, Salt Lake City
- DOE Contract Number:
- EY-76-C-02-0119
- OSTI ID:
- 5098999
- Journal Information:
- Radiat. Res.; (United States), Vol. 83:1
- Country of Publication:
- United States
- Language:
- English
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BEAGLES
SENSITIVITY
URANIUM 233
RADIONUCLIDE KINETICS
BIOLOGICAL LOCALIZATION
BLOOD PLASMA
COMPARATIVE EVALUATIONS
EXCRETION
INTRAVENOUS INJECTION
KIDNEYS
OSTEOSARCOMAS
PLUTONIUM 239
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RADIUM 226
RETENTION
SKELETON
TISSUE DISTRIBUTION
TOXICITY
URANIUM 232
URINE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CLEARANCE
DISEASES
DISTRIBUTION
DOGS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
HEAVY NUCLEI
INJECTION
INTAKE
ISOTOPES
MAMMALS
MATERIALS
NEOPLASMS
NUCLEI
ORGANS
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIUM ISOTOPES
SARCOMAS
SKELETAL DISEASES
URANIUM ISOTOPES
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)