Comparison of early mortality in baboons and dogs after inhalation of /sup 239/PuO/sub 2/

Journal Article · Sun Jun 01 00:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575325· OSTI ID:5098980

Bair, W J ^[1]; Metivier, H; Park, J F; Masse, R; Stevens, D L; Lafuma, J; Watson, C R; Nolibe, D

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1. Battelle Pacific Northwest Lab., Richland, WA

Results from experiments with baboons were compared with those from experiments with dogs to determine the relative sensitivity of the two species to early mortality from inhaled /sup 239/PuO/sub 2/. To ensure a valid comparison of data developed at two laboratories, methodology differences were minimized by establishing a common pool of raw data, using the same computer programs to analyze the data, and standardizing assumptions regarding the calculation of plutonium concentration in lungs. Several comparison methods were used involving variations in estimating different parameters used in these calculations. Although nearly all comparisons suggested baboons were slightly more sensitive, none of the methods for comparing the relationship between dose and survival time showed consistently significant differences between baboons and dogs. Although the baboons were physiologically and morphologically immature when exposed to plutonium, whereas the dogs were mature, we concluded that adult baboons and dogs are similarly sensitive to the early effects of inhaled /sup 239/PuO/sub 2/. Since only early mortality was considered in this comparison, the results do not apply to possible late effects caused by much lower levels of plutonium than were used in these experiments.

• DOE Contract Number: EY-76-C-06-1830
• OSTI ID: 5098980
• Journal Information: Radiat. Res.; (United States), Vol. 82:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
APES
EARLY RADIATION EFFECTS
DEATH
RADIOINDUCTION
DOGS
PLUTONIUM 239
TOXICITY
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
INHALATION
LUNGS
MORTALITY
PLUTONIUM OXIDES
RADIOSENSITIVITY
SURVIVAL TIME
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHALCOGENIDES
EVEN-ODD NUCLEI
HEAVY NUCLEI
INTAKE
ISOTOPES
MAMMALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PRIMATES
RADIATION EFFECTS
RADIOISOTOPES
RESPIRATORY SYSTEM
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
550100 - Behavioral Biology