Lack of teratogenic and mutagenic effects of nitrite on mouse fetuses

Journal Article · Sat Oct 01 00:00:00 EDT 1988 · Environmental Research; (USA)

OSTI ID:5098672

Shimada, Takamichi ^[1]

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1. Yamagata Univ. School of Medicine (Japan)

To assess embryotoxic effects of sodium nitrite, pregnant ICR mice were given drinking water containing sodium nitrite at a concentration of either 100 or 1,000 mg/L on days 7-18 of gestation. There were no significant differences between treated and control groups in measures of developmental toxicity, e.g., litter size, fetal weight, and number of resorbed or dead fetuses. The incidences of external and skeletal malformations in fetuses of treated groups were not significantly different from those in the controls. No significant increase was observed in the frequency of gaps and breaks of liver cell chromosomes in fetuses exposed in utero to sodium nitrite. Teratogenic and mutagenic effects of sodium nitrite were absent in mice at the doses used.

• OSTI ID: 5098672
• Journal Information: Environmental Research; (USA), Vol. 47:1; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NITRITES
TOXICITY
CHROMOSOMES
DRINKING WATER
FETUSES
MICE
MUTAGEN SCREENING
PRENATAL EXPOSURE
SODIUM COMPOUNDS
TERATOGEN SCREENING
ALKALI METAL COMPOUNDS
ANIMALS
HYDROGEN COMPOUNDS
MAMMALS
NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
RODENTS
SCREENING
VERTEBRATES
WATER
560300* - Chemicals Metabolism & Toxicology