Incorporation of /sup 14/C from glucose into amino acids in brain in vitro in the presence of organo- and inorganic lead and pyridoxal phosphate

Journal Article · Mon Dec 05 00:00:00 EST 1983 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(83)90260-6· OSTI ID:5095862

Regunathan, S; Sundaresan, R

The incorporation of label from U/sup 14/C glucose into glutamic acid, glutamine and GABA remained unaltered with the presence of lead acetate in the medium whereas tetraethyl lead (TEL) affected the incorporation in a characteristic manner in different regions of brain. Glucose uptake however was not influenced by TEL. Pyridoxal phosphate was found to reverse the effect of TEL on the incorporation especially in cerebellum and brainstem but with little effect in cerebral cortex. These findings suggest that the alterations in the GABA metabolism in TEL toxicity could be restored to some extent by pyridoxine in discrete brain areas.

• Research Organization: Jawaharlal Inst. of Postgraduate Medical Education and Research, India
• OSTI ID: 5095862
• Journal Information: Life Sci.; (United States), Vol. 33:23
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CARBON 14 COMPOUNDS
UPTAKE
GLUCOSE
LEAD COMPOUNDS
BIOLOGICAL EFFECTS
PHOSPHATES
TEL
ACETATES
AMINO ACIDS
BRAIN
IN VITRO
RATS
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
HEXOSES
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
RODENTS
SACCHARIDES
VERTEBRATES
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