Age-related differences in the bone mineralization pattern of rats following exercise
The effect of 12 weeks of treadmill exercise on the mineralization of trabecular and cortical bone was studied in rats 7, 14, and 19 months of age. Bone mineralization was evaluated by measuring concentrations of Ca, Mg, and hydroxyproline as well as uptake of 45Ca concentration in the femur, humerus, rib and calvaria. The 7- and 14-month-old rats increased mineralization in those cortical bones directly involved in exercise. The 19-month animal responded to exercise by increasing mineralization in all bones examined, including the nonweight bearing trabecular calvaria and cortical rib. From these data, it is apparent that the older animals undergo a total skeletal mineralization in response to exercise compared with local adaptation in the younger animal. Further, we provide evidence to support the use of the rat as a model in which to study mammalian bone physiology during the aging process.
- OSTI ID:
- 5092845
- Journal Information:
- J. Gerontol.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
EXERCISE
BIOLOGICAL EFFECTS
SKELETON
MINERALIZATION
CALCIUM
CALCIUM 45
FEMUR
HYDROXYPROLINE
MAGNESIUM
METABOLISM
PHOSPHORUS
RATS
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
AMINES
AMINO ACIDS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCIUM ISOTOPES
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
METALS
NONMETALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRROLES
PYRROLIDINES
RADIOISOTOPES
RODENTS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques