Increased IgE antibody responses in rats exposed to tobacco smoke
Raised serum IgE levels were found in a high proportion of rats that had been exposed to tobacco smoke twice daily 5 days a week for 8 wk in a Dontenville-type smoking machine. Levels above 1 ng/ml of IgE were found in nine of 20 animals exposed to cigarette smoke and in five of 20 rats exposed to smoke from cigarettes with 1.45% phenylmethyloxidiazole added for possible protection against the effects of the smoke. None of the 20 control rats exhibited similarly increased serum IgE. Exposure to tobacco smoke did not significantly affect the serum concentrations of IgM and IgG. The development of specific IgE and IgG antibodies was also influenced by tobacco smoke exposure. Rats exposed to ovalbumin aerosol developed increased levels of IgG and IgE antibodies, whereas no effect on the development of antibody titers was found in rats immunized by the subcutaneous route. This study demonstrates that exposure to tobacco smoke increases serum IgE levels and enhances sensitization via the airways by a local effect, thus supporting the mucosal theory of atopy.
- Research Organization:
- Karolinska Hospital, Stockholm, Sweden
- OSTI ID:
- 5090892
- Journal Information:
- J. Allergy Clin. Immunol.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
RATS
ANTIBODY FORMATION
TOBACCO SMOKES
BIOLOGICAL EFFECTS
IMMUNOGLOBULINS
OXADIAZOLES
TOBACCO
AEROSOLS
ANIMALS
AZOLES
COLLOIDS
DISPERSIONS
GLOBULINS
HETEROCYCLIC COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PROTEINS
RESIDUES
RODENTS
SMOKES
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)