Regional distribution of immunoreactive endothelin in rats
- National Cardiovascular Center Research Institute and Hospital, Osaka (Japan)
By use of a specific radioimmunoassay for endothelin (ET), the regional distribution of ET-like immunoreactivity (LI) was studied in rats. The antiserum used cross-reacted equally with synthetic porcine and rat ET. Significant amounts of ET-LI are detectable not only in aorta, but also in kidney, lung, heart, liver and central nervous system. Gel chromatography of the tissue extracts revealed size heterogeneity of ET-LI; one major component eluting close to, but slightly larger than standard rat ET and the other minor component with a larger molecular weight. These data indicate that ET-LI is widely distributed throughout the various rat tissues, suggesting its possible involvement in a variety of organ functions.
- OSTI ID:
- 5085530
- Journal Information:
- Peptides (Fayetteville, New York); (USA), Vol. 10:4; ISSN 0196-9781
- Country of Publication:
- United States
- Language:
- English
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550201* - Biochemistry- Tracer Techniques