Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina
- Univ. of Texas Southwestern Medical Center, Dallas, TX (United States)
We recently cloned three membrane guanylyl cyclases, designated GC-D, CG-E, and GC-F, from rat olfactory tissue and eye. Amino acid sequence homology suggests that they may compose a new gene subfamily of guanylyl cyclase receptors specifically expressed in sensory tissues. Their chromosomal localization was determined by mouse interspecific backcross analysis. The GC-D, CG-E, and GC-F genes (Gucy2d, Gucy2e, and Gucy2f) are dispersed through the mouse genome in that they map to chromosomes 7, 11, and X, respectively. Close proximity of the mouse GC-D gene to Omp (olfactory marker protein) and Hbb (hemoglobin {beta}-chain complex) suggests that the human homolog gene maps to 11p15.4 or 11q13.4-q14.1. The human GC-F gene was localized to the long arm of chromosome Xq22 by fluorescence in situ hybridization. The genomic organization of the mouse GC-E, and GC-F genomic clones contain identical exon-intron boundaries within their extracellular and cytoplasmic domains, demonstrating the conservation of the gene structures. With respect to human genetic diseases, GC-E mapped to mouse chromosome 11 within a syntenic region on human chromosome 17p13 that has been linked with loci for autosomal dominant retinitis pigmentosa and Leber congenital amaurosis. No apparent disease loci have been yet linked to the locations of the GC-D or GC-F genes. 39 refs., 3 figs., 2 tabs.
- OSTI ID:
- 508337
- Journal Information:
- Genomics, Vol. 31, Issue 3; Other Information: PBD: 1 Feb 1996
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BASIC STUDIES
CHROMOSOMES
GENETIC MAPPING
HUMAN CHROMOSOMES
HUMAN X CHROMOSOME
HUMAN CHROMOSOME 17
HEREDITARY DISEASES
GENETICS
CYCLASES
GENE REGULATION
STRUCTURE-ACTIVITY RELATIONSHIPS
DNA-CLONING
TISSUE DISTRIBUTION
RECEPTORS
RATS
MICE
DNA HYBRIDIZATION
FLUORESCENCE
SENSE ORGANS DISEASES
DOMINANT MUTATIONS
AMINO ACID SEQUENCE
NERVE CELLS
PROBES
RETINA
OLFACTORY BULBS