CONTIG EXPLORER: Interactive marker-content map assembly

Journal Article · Thu Feb 01 00:00:00 EST 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0052· OSTI ID:508329

Nadkarni, P M; Miller, P; Banks, A ^[1]

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1. Yale School of Medicine, New Haven, CT (United States); and others

In STS-content mapping of a region, multiple optimal or near-optimal putative orders of markers exist. Determining which of the markers lack sufficient evidence to be placed requires software that facilitates exploratory sensitivity analysis and interactive reassembly with different subsets of the input data and that also assists the evaluation of any arbitrary (user-specified) marker order. We describe CONTIG EXPLORER, a package for interactive assembly of STS-content maps that provides the user with various ways of performing such analysis, thereby facilitating the design of laboratory experiments aimed at reducing ambiguity in STS order. We then compare the output of CONTIG EXPLORER with two other assembly programs, SEGMAP and CONTIGMAKER, for a region of chromosome 12p between 21 and 38 cM on the sex-averaged CEPH/Genethon linkage map. 18 refs., 4 figs.

• OSTI ID: 508329
• Journal Information: Genomics, Vol. 31, Issue 3; Other Information: PBD: 1 Feb 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
44 INSTRUMENTATION
INCLUDING NUCLEAR AND PARTICLE DETECTORS
99 MATHEMATICS
COMPUTERS
INFORMATION SCIENCE
MANAGEMENT
LAW
MISCELLANEOUS
GENETIC MAPPING
C CODES
S CODES
ACCURACY
RELIABILITY
OPTIMIZATION
ALGORITHMS
CONTIGS
DESIGN
HUMAN CHROMOSOMES
QUANTITATIVE CHEMICAL ANALYSIS
DNA-CLONING
CHROMOSOMAL ABERRATIONS
HUMAN CHROMOSOME 12
BIOLOGICAL MARKERS
PROBES