Solid-state /sup 13/C NMR and X-ray diffraction of dermatan sulfate
Dermatan sulfate in the solid state has been studied by /sup 13/C CP/MAS nmr and X-ray diffraction in order to establish the ring conformation of the L-iduronate moiety. The solid state nmr spectrum is similar to the solution spectrum obtained previously, indicating that a ring conformation at least approximating to /sup 1/C/sub 4/ predominates in the solid state. X-ray powder diffraction data from the same sample indicate the presence of the 8-fold helix form previously observed by fiber diffraction, and interpreted in terms of a /sup 4/C/sub 1/ ring form. A likely explanation of the results is that a distorted /sup 1/C/sub 4/ L-iduronate ring conformation, not considered in the initial X-ray analysis, may emerge to provide a satisfactory interpretation of all available physical-chemical data.
- Research Organization:
- Polytechnic Univ., Brooklyn, NY
- OSTI ID:
- 5080318
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Vol. 137:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CHONDROITIN
NUCLEAR MAGNETIC RESONANCE
STRUCTURAL CHEMICAL ANALYSIS
X-RAY DIFFRACTION
CARBON 13
EXPERIMENTAL DATA
HELICAL CONFIGURATION
AMINES
CARBOHYDRATES
CARBON ISOTOPES
COHERENT SCATTERING
CONFIGURATION
DATA
DIFFRACTION
EVEN-ODD NUCLEI
INFORMATION
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MUCOPOLYSACCHARIDES
NUCLEI
NUMERICAL DATA
ORGANIC COMPOUNDS
POLYSACCHARIDES
RESONANCE
SACCHARIDES
SCATTERING
STABLE ISOTOPES
400104* - Spectral Procedures- (-1987)
400301 - Organic Chemistry- Chemical & Physicochemical Properties- (-1987)