Effect of MSH/ACTH peptides on fast axonal transport in intact and regenerating sciatic nerves

Thesis/Dissertation · Tue Jan 01 00:00:00 EST 1985

OSTI ID:5071491

Crescitelli, L A

Fast axonal transport was examined in intact rats treated with ACTH 4-10 or ACTH 4-9 (ORG 2766), hypophysectomized rats, adrenalectomized rats, and in ACTH 4-10 treated rats with crushed regenerating sciatic nerves by injecting /sup 3/H-leucine into the ventral horn region of the spinal cord. The distance traveled by the transported activity along the sciatic nerve and the rate of fast axonal transport were not significantly altered as a result of treatment with ACTH 4-10, ACTH 4-9 (ORG 2766), hypophysectomy, or adrenalectomy. Treatment with ACTH 4-9 (ORG 2766) at concentrations of 1 ..mu..g/Kg /day and 10 ..mu..g/Kg/day caused significant reductions (62% and 64% respectively) in the crest height of the fast axonal transport curve as compared to 0.9% saline treated control animals. No significant differences were found in comparing the distance, rate, slope, or crest height of ACTH 4-10 treated animals with crushed regenerating (7 or 14d) sciatic nerves to control animals. In the group of animals in days, the amount of radiolabeled activity was significantly increased in the ACTH 4-10 treated animals as compared to control animals. The results indicate that during regeneration the peptide acts to prolong the initially high levels of synthetic activity which occur in regenerating axons.

• Research Organization: New York Univ., NY (USA)
• OSTI ID: 5071491
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTH
BIOLOGICAL EFFECTS
SCIATIC NERVE
RADIONUCLIDE KINETICS
ADRENALECTOMY
BIOELECTRICITY
BIOLOGICAL REGENERATION
HYPOPHYSECTOMY
LEUCINE
RATS
TRITIUM COMPOUNDS
AMINO ACIDS
ANIMALS
BIOLOGICAL RECOVERY
CARBOXYLIC ACIDS
ELECTRICITY
HORMONES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
NERVES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
RECOVERY
RODENTS
SURGERY
VERTEBRATES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)