Pharmacokinetics and expert systems as aids for risk assessment in reproductive toxicology

Journal Article · Tue Dec 01 00:00:00 EST 1987 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8776107· OSTI ID:5067869

Mattison, D R; Jelovsek, F R

A minimal approach to risk assessment in reproductive toxicology involves four components: hazard identification, hazard characterization, exposure characterization, and risk characterization. In practice, risk assessment in reproductive toxicology has been reduced to arbitrary safety factors or mathematical models of the dose-response relationship. These approaches obscure biological differences across species rather than using this important and frequently accessible information. Two approaches that are formally capable of using biologically relevant information (pharmacokinetics and expert system shells) are explored as aids to risk assessment in reproductive toxicology.

• Research Organization: Univ. of Arkansas for Medical Sciences, Little Rock (USA)
• OSTI ID: 5067869
• Journal Information: Environ. Health Perspect.; (United States), Vol. 76
• Country of Publication: United States
• Language: English

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DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
TERATOGENESIS
RISK ASSESSMENT
XENOBIOTICS
BIOLOGICAL EFFECTS
CAFFEINE
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DRUGS
FETAL MEMBRANES
HETEROCYCLIC COMPOUNDS
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MERCURY COMPOUNDS
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ORGANIC COMPOUNDS
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ORGANIC NITROGEN COMPOUNDS
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560300* - Chemicals Metabolism & Toxicology