Solubility properties in polymers and biological media. 7. An analysis of toxicant properties that influence inhibition of bioluminescence in photobacterium phosphoreum (the Microtox test)

Journal Article · Tue Jul 01 00:00:00 EDT 1986 · Environ. Sci. Technol.; (United States)

DOI:https://doi.org/10.1021/es00149a007· OSTI ID:5067361

Kamlet, M J; Doherty, R M; Veith, G D; Taft, R W; Abraham, M H

Inhibition of bioluminescence in Photobacterium phosphoreum (the Microtox test) has been proposed as a cost-effective prescreening procedure to eliminate the relatively more innocuous chemicals from testing programs for toxicities of organic chemicals to fish. The biological response, as a function of toxicant properties, is given by log EC/sub 50/ (in ..mu..molL) = 7.61 - 4.11 anti V100 - 1.54 ..pi..* + 3.94..beta.. - 1.51..cap alpha../sub m/ n = 38, r = 0.987, SD = 0.28 where anti V is the solute molar volume and ..pi..*, ..beta.., and ..cap alpha../sub m/ are the solvatochromic parameters that measure dipolaritypolarizability, hydrogen-bond acceptor basicity, and hydrogen-bond donor acidity of the solute (toxicant). The above equation applies to compounds that act by a nonreactive toxicity mechanism, and it is suggested that for certain compounds, which are outliers relative to the above equation, reactive toxicity properties mask the effects of the nonreactive mechanism. The above equation is compared with a correlation of log EC/sub 50/ with octanolwater partition coefficients. 25 references, 2 figures, 2 tables.

• Research Organization: Naval Surface Weapons Center, Silver Spring, MD (USA)
• OSTI ID: 5067361
• Journal Information: Environ. Sci. Technol.; (United States), Vol. 20:7
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ORGANIC COMPOUNDS
SOLUBILITY
TOXICITY
PHOTOSYNTHETIC BACTERIA
BIOLUMINESCENCE
EQUATIONS
EXPERIMENTAL DATA
FISHES
INHIBITION
ANIMALS
AQUATIC ORGANISMS
DATA
INFORMATION
LUMINESCENCE
NUMERICAL DATA
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology