The interleukin 2 gene is expressed in the syncytiotrophoblast of the human placenta
- Case Western Reserve Univ. School of Medicine, Cleveland, OH (USA)
The lymphokine interleukin 2 is an important immune system regulatory glycopolypeptide. It is produced by antigen- or mitogen-stimulated T lymphocytes and is required for the proliferation or clonal expansion of activated T lymphocytes. In this report, it is demonstrated by RNA transfer blot hybridization that the poly(A){sup +} RNA population of the human placenta contains a 0.85-kilobase RNA transcript that specifically hybridizes to a human interleukin 2 cDNA probe. By using hybridization histochemistry in situ, it is further shown that interleukin 2 RNA transcripts are localized, primarily, to the syncytial (syncytiotrophoblast) layer of the human placenta. Possible roles for syncytiotrophoblast-produced interleukin 2 are suggested and discussed.
- OSTI ID:
- 5049071
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 86:2; ISSN 0027-8424
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
LYMPHOCYTES
CELL PROLIFERATION
LYMPHOKINES
GENE REGULATION
MESSENGER-RNA
DNA HYBRIDIZATION
RECOMBINANT DNA
AUTORADIOGRAPHY
GLYCOPROTEINS
NUCLEOTIDES
PHOSPHORUS 32
PLACENTA
WOMEN
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DNA
FEMALES
FETAL MEMBRANES
GROWTH FACTORS
HYBRIDIZATION
ISOTOPES
LEUKOCYTES
LIGHT NUCLEI
MAMMALS
MAN
MATERIALS
MEMBRANES
MITOGENS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHOSPHORUS ISOTOPES
PRIMATES
PROTEINS
RADIOISOTOPES
RNA
SOMATIC CELLS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550401 - Genetics- Tracer Techniques