Current research of the Environmental Protection Agency on automotive-criteria pollutants
The HERL conducts a variety of investigations of the health effects of air pollutants to serve as criteria for the reevaluation of National Ambient Air Quality Standards. Human clinical studies include research on the effects of: (1) ozone (O/sub 3/) and nitrogen dioxide (NO/sub 2/) on exercising healthy adults, asthmatics, males vs. females, and blacks vs. whites; (2) O/sub 3/ and NO/sub 2/ on pulmonary cell biology and immunology; (3) carbon monoxide (CO) on cardiovascular physiology of patients with ischemic heart disease; and (4) CO on neurophysiology. Human research also includes investigation of the mechanisms of the effects of O/sub 3/ and NO/sub 2/ and the relationship between rate of exposure to CO and the level of carboxyhemoglobin formation and effects. The neurophysiological effects of lead are being investigated in humans and monkeys. Animal studies with O/sub 3/ and NO/sub 2/ include: (1) evaluation of the progression of chronic lung disease during chronic exposure, (2) determination of the effects on antiviral lung diseases, and (3) investigation of the mechanisms of effects. Quantitative animal-to-man extrapolation models for O/sub 3/ and NO/sub 2/ focused on dosimetry and species sensitivity, are under development.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5048702
- Report Number(s):
- PB-85-218907/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
33 ADVANCED PROPULSION SYSTEMS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR QUALITY
CARBON MONOXIDE
HEALTH HAZARDS
LEAD
BIOLOGICAL EFFECTS
NITROGEN DIOXIDE
OZONE
ASTHMA
EXTRAPOLATION
LABORATORY ANIMALS
MATHEMATICAL MODELS
NEUROLOGY
PUBLIC HEALTH
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
DISEASES
ELEMENTS
ENVIRONMENTAL QUALITY
HAZARDS
MEDICINE
METALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
NUMERICAL SOLUTION
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM DISEASES
500200* - Environment
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330700 - Advanced Propulsion Systems- Emission Control
560306 - Chemicals Metabolism & Toxicology- Man- (-1987)