Postirradiation sarcomas of the head and neck

Journal Article · Fri Sep 01 00:00:00 EDT 1989 · Ear, Nose and Throat Journal; (USA)

OSTI ID:5045237

Maisel, R H; Manivel, J C; Porto, D P; Stanley, M

We discuss four cases of postirradiation sarcomas of the head and neck. Two cases were metachronous sarcomas that appeared after operation and irradiation for primary sarcomas, 1 case was a mandibular malignant fibrous histiocytoma that developed on the opposite side of the jaw from a malignant histiocytic neoplasm that was irradiated 8 years previously, and 1 case was a laryngeal tumor that appeared 5 years after combined operative and radiation therapy for a laryngeal squamous carcinoma. Immunohistochemical studies more precisely defined and classified these tumors, and assisted in determining a therapeutic protocol. The therapy for postirradiation sarcomas includes extirpative operation when possible, but the role of chemotherapy is uncertain. The aggressive behavior of these neoplasms was attested to by the death of three patients within 18 months of their operations.

• OSTI ID: 5045237
• Journal Information: Ear, Nose and Throat Journal; (USA), Vol. 68:9; ISSN 0145-5613
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HEAD
SARCOMAS
NECK
RADIOTHERAPY
SIDE EFFECTS
RADIOINDUCTION
DELAYED RADIATION EFFECTS
PATIENTS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DISEASES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
THERAPY
560151* - Radiation Effects on Animals- Man