Automated quantitation of three-dimensional cardiac positron emission tomography for routine clinical use
- Univ. of Texas Health Science Center, Houston (USA)
Visual comparison of rest/stress cardiac positron emission tomography indicates coronary flow reserve for diagnosing and assessing severity of coronary artery disease. An accurate, rapid, automated method for comparison and quantitation of paired cardiac PET studies has been developed to analyze size, intensity, statistical significance of and changes in perfusion or metabolism. The method utilizes polar coordinate maps derived from circumferential profiles of true short axis slices; from the short axis data algorithms determine mean and minimum activity levels in the anterior, septal, lateral, inferior and apical regions of the myocardium, percent of the cardiac image in specific ranges of activity levels or their changes and the percent of myocardium beyond 1.5, 2.0, and 2.5 standard deviations from the normal range with blackout display of the areas beyond these statistical limits for rest, stress, and stress/rest ratio polar maps. Additional applications include comparing stress-stress images to evaluate progression/regression of stenoses, early and late resting rubidium images for determining myocardial viability based on rubidium washout kinetics, and perfusion-metabolic comparisons for quantifying ischemia, viability and necrosis after acute myocardial infarction.
- OSTI ID:
- 5043468
- Journal Information:
- Journal of Nuclear Medicine; (USA), Vol. 30:11; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
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CARDIOVASCULAR DISEASES
DIAGNOSIS
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POSITRON COMPUTED TOMOGRAPHY
ALGORITHMS
BLOOD FLOW
EXERCISE
MAN
METABOLISM
MYOCARDIAL INFARCTION
PERFUSED ORGANS
RUBIDIUM ISOTOPES
ALKALI METAL ISOTOPES
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
ISOTOPES
MAMMALS
MATHEMATICAL LOGIC
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TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics