Comparative dual-tracer studies of carbon-14 tryptophan and iodine-131 HIPDM in animal models of pancreatic diseases

Journal Article · Wed Nov 01 00:00:00 EST 1989 · Journal of Nuclear Medicine; (USA)

OSTI ID:5043306

Kubota, K; Som, P; Brill, A B; Sacker, D F; Meinken, G E; Srivastava, S C; Atkins, H L ^[1]

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1. Brookhaven National Lab., Upton, NY (USA)

Our previous studies have shown that a significant amount of the diamine derivative {sup 131}I-N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3- propanediamine (HIPDM) is taken up and retained by the normal pancreas. Therefore, we studied the uptake of ({sup 13}1I)HIPDM in various pathophysiological models in mice (chronic alcoholism, diabetes with beta-cell atrophy and obesity with beta-cell hypertrophy) and compared to {sup 14}C-L-Tryptophan (TRY) distribution in order to determine the factors influencing their pancreatic uptake. In normal animals, the pancreas uptake of TRY was generally higher than HIPDM. In diabetes, the relative concentration of both compounds was higher over the controls; however, in obesity, TRY showed lower accumulation than in controls while HIPDM showed no significant difference. Chronic ethanol (20%) ingestion increased TRY uptake in the pancreas compared to controls (36.88 {plus minus} 3.21 vs. 30.03 {plus minus} 4.17% ID/g; p less than 0.01) after 5 wk study period, but it decreased by 10 wk (22.36 {plus minus} 0.95% ID/g; p less than 0.005). There were no significant changes in ({sup 131}I)HIPDM distribution in alcoholics as compared to the controls. Radioiodinated HIPDM has potential advantages over ({sup 11}C)TRY for pancreatic imaging since conventional imaging techniques can be employed. Our data, however, suggest that {sup 11}C-L-TRY is a more sensitive indicator of various pancreatic disorders.

• OSTI ID: 5043306
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 30:11; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
METABOLIC DISEASES
DIAGNOSIS
RADIOPHARMACEUTICALS
UPTAKE
AUTORADIOGRAPHY
BIOLOGICAL MODELS
CARBON 11
CARBON 14 COMPOUNDS
COMPARATIVE EVALUATIONS
DIABETES MELLITUS
IODINE 131
MICE
TISSUE DISTRIBUTION
TRYPTOPHAN
WHOLE-BODY COUNTING
AMINO ACIDS
ANIMALS
AROMATICS
AZAARENES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON ISOTOPES
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
DRUGS
ENDOCRINE DISEASES
EVEN-ODD NUCLEI
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRROLES
RADIOISOTOPES
RODENTS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics