Dose-excretion relationship in tetrachloroethylene-exposed workers and the effect of tetrachloroethylene co-exposure on trichloroethylene metabolism
- Tohoku Univ. School of Medicine, Sendai (Japan)
Personal monitoring of 8-hour time-weighted average intensity of exposure with diffuse samplers and analysis of shift-end urine for total trichloro-compounds (TTC) and other metabolites were conducted in two groups of workers in China, one (121 subjects) exposed to tetrachloroethylene (TETRA) alone, and the other (38 subjects) exposed to a mixture of TETRA and trichloroethylene (TRI). Urinalysis was also performed on samples from 103 non-exposed controls. A linear exposure-excretion relationship could be observed in both groups of workers. Comparison of these results with those of Japanese TETRA-workers suggested the presence of ethnic difference in TETRA metabolism. Urinary metabolite levels were markedly lower in the mixed (TETRA + TRI) exposure group as compared to previous findings in a group exposed to TRI alone. The observation indicates that metabolism of TRI is suppressed by the co-exposure to TETRA in humans.
- OSTI ID:
- 5043296
- Journal Information:
- American Journal of Industrial Medicine; (USA), Vol. 16:6; ISSN 0271-3586
- Country of Publication:
- United States
- Language:
- English
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CHLORINATED ALIPHATIC HYDROCARBONS
METABOLISM
AIR POLLUTION
CHINA
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
JAPAN
METABOLITES
OCCUPATIONAL EXPOSURE
PERSONNEL
REGRESSION ANALYSIS
ASIA
HALOGENATED ALIPHATIC HYDROCARBONS
MATHEMATICS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
POLLUTION
STATISTICS
560300* - Chemicals Metabolism & Toxicology