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Title: Effect of the serotonin antagonist ketanserin on the hemodynamic and morphological consequences of thrombotic infarction

Abstract

The effect of the serotonin (5-hydroxytryptamine, 5-HT) antagonist ketanserin on the remote hemodynamic consequences of thrombotic brain infarction was studied in rats. Treated rats received an injection of 1 mg/kg ketanserin 30 min before and 1 h following photochemically induced cortical infarction. Local CBF (LCBF) was assessed autoradiographically with ({sup 14}C)iodoantipyrine 4 h following infarction, and chronic infarct size was documented at 5 days. Thrombotic infarction led to significant decreases in LCBF within noninfarcted cortical regions. For example, mean LCBF was decreased to 63, 55, and 65% of control (nontreated normal rats) in ipsilateral frontal, lateral, and auditory cortices, respectively. In rats treated with ketanserin, significant decreases in LCBF were not documented within remote cortical areas compared with controls. In contrast to these hemodynamic effects, morphological analysis of chronic infarct size demonstrated no differences in infarct volume between treated (27 +/- 3 mm3) and nontreated (27 +/- 6 mm3) rats. These data are consistent with the hypothesis that 5-HT is involved in the widespread hemodynamic consequences of experimentally induced thrombotic infarction. Remote hemodynamic consequences of acute infarction can be inhibited without altering final infarct size.

Authors:
; ;  [1]
  1. Univ. of Miami School of Medicine, FL (USA)
Publication Date:
OSTI Identifier:
5032984
Resource Type:
Journal Article
Journal Name:
Journal of Cerebral Blood Flow and Metabolism; (USA)
Additional Journal Information:
Journal Volume: 9:6; Journal ID: ISSN 0271-678X
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; SEROTONIN; BIOLOGICAL FUNCTIONS; VASCULAR DISEASES; PATHOGENESIS; AUTORADIOGRAPHY; BRAIN; CARBON 14 COMPOUNDS; MORPHOLOGY; RATS; AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BODY; CENTRAL NERVOUS SYSTEM; DISEASES; DRUGS; FUNCTIONS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; LABELLED COMPOUNDS; MAMMALS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRROLES; RADIOPROTECTIVE SUBSTANCES; RODENTS; SYMPATHOMIMETICS; TRYPTAMINES; VERTEBRATES; 550901* - Pathology- Tracer Techniques

Citation Formats

Dietrich, W D, Busto, R, and Ginsberg, M D. Effect of the serotonin antagonist ketanserin on the hemodynamic and morphological consequences of thrombotic infarction. United States: N. p., 1989. Web. doi:10.1038/jcbfm.1989.115.
Dietrich, W D, Busto, R, & Ginsberg, M D. Effect of the serotonin antagonist ketanserin on the hemodynamic and morphological consequences of thrombotic infarction. United States. https://doi.org/10.1038/jcbfm.1989.115
Dietrich, W D, Busto, R, and Ginsberg, M D. 1989. "Effect of the serotonin antagonist ketanserin on the hemodynamic and morphological consequences of thrombotic infarction". United States. https://doi.org/10.1038/jcbfm.1989.115.
@article{osti_5032984,
title = {Effect of the serotonin antagonist ketanserin on the hemodynamic and morphological consequences of thrombotic infarction},
author = {Dietrich, W D and Busto, R and Ginsberg, M D},
abstractNote = {The effect of the serotonin (5-hydroxytryptamine, 5-HT) antagonist ketanserin on the remote hemodynamic consequences of thrombotic brain infarction was studied in rats. Treated rats received an injection of 1 mg/kg ketanserin 30 min before and 1 h following photochemically induced cortical infarction. Local CBF (LCBF) was assessed autoradiographically with ({sup 14}C)iodoantipyrine 4 h following infarction, and chronic infarct size was documented at 5 days. Thrombotic infarction led to significant decreases in LCBF within noninfarcted cortical regions. For example, mean LCBF was decreased to 63, 55, and 65% of control (nontreated normal rats) in ipsilateral frontal, lateral, and auditory cortices, respectively. In rats treated with ketanserin, significant decreases in LCBF were not documented within remote cortical areas compared with controls. In contrast to these hemodynamic effects, morphological analysis of chronic infarct size demonstrated no differences in infarct volume between treated (27 +/- 3 mm3) and nontreated (27 +/- 6 mm3) rats. These data are consistent with the hypothesis that 5-HT is involved in the widespread hemodynamic consequences of experimentally induced thrombotic infarction. Remote hemodynamic consequences of acute infarction can be inhibited without altering final infarct size.},
doi = {10.1038/jcbfm.1989.115},
url = {https://www.osti.gov/biblio/5032984}, journal = {Journal of Cerebral Blood Flow and Metabolism; (USA)},
issn = {0271-678X},
number = ,
volume = 9:6,
place = {United States},
year = {Fri Dec 01 00:00:00 EST 1989},
month = {Fri Dec 01 00:00:00 EST 1989}
}