Radioaerosol lung clearance in patients with active pulmonary sarcoidosis
Pulmonary radioaerosol clearance rate of /sup 99m/Tc diethylenetriamine pentacetate (DTPA) in 14 patients with untreated sarcoidosis was compared with /sup 67/Ga lung scan and increased lymphocytes in the bronchoalveolar lavage (BAL) fluid. Nine healthy nonsmoking subjects had a mean DTPA clearance rate of 1.18%/min (range, 0.54 to 1.60%/min). Eight of 14 patients with sarcoidosis had clearance rates greater than 1.60%/min. Of those 8 patients with abnormal DTPA clearance, 4 had positive gallium scans, 4 had more than 17% lymphocytes in the BAL fluid, and 3 had both tests positive. To study the cause of abnormal DTPA clearance, 23 subjects (including 3 normal controls, all 14 patients with sarcoidosis, and 6 patients with localized disease on chest roentgenogram) underwent both DTPA clearance studies and BAL for quantitation of the amount of albumin in lung fluid. There was a positive correlation between the rate of DTPA clearance and the albumin concentration in lung fluid (r = 0.87, p less than 0.01).
- OSTI ID:
- 5029947
- Journal Information:
- Am. Rev. Respir. Dis.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Asbestosis. Bronchoalveolar lavage fluid proteins and their relationship to pulmonary epithelial permeability
Sarcoidosis: correlation of pulmonary parenchymal pattern at CT with results of pulmonary function tests
Related Subjects
AEROSOLS
LUNG CLEARANCE
LUNGS
RADIOISOTOPE SCANNING
ALBUMINS
COMPARATIVE EVALUATIONS
DTPA
GALLIUM 67
ISOMERIC NUCLEI
LABELLED COMPOUNDS
LAVAGE
LYMPHOCYTES
PATIENTS
RESPIRATORY SYSTEM DISEASES
TECHNETIUM 99
TOBACCO SMOKES
TRACER TECHNIQUES
AMINO ACIDS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
DISPERSIONS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
GALLIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESIDUES
RESPIRATORY SYSTEM
SMOKES
SOLS
SOMATIC CELLS
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics