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Title: Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma

Abstract

Thirty (3.8%) of 780 patients with differentiated thyroid cancer seen between 1970 and 1987 had bone metastases. The primary tumor was follicular in 26 patients and papillary in four. Mean age at diagnosis was 61 years. The manifestation of bone metastases was the presenting symptom in 18 patients (60%). Treatment included total thyroidectomy, levothyroxine sodium therapy, and radioactive iodine treatments. Twenty-seven patients had bone metastases from the initial observation, with 44 sites involved. Of the sites, 27 (61%) were shown both on iodine 131 whole-body scan (WBS) and on x-ray film, 11 (25%) only on WBS, and six (14%) only on x-ray film. Multiple involvement was observed in 11 patients. The radiologic appearance was invariably osteolytic. Serum thyroglobulin was elevated in all patients. After radioactive iodine, no WBS+/X-ray+ metastases showed a complete response, although a sclerotic border was noted in several cases, whereas six WBS+/X-ray- lesions were no longer detectable by WBS. Treatment with radioactive iodine and bone surgery resulted in a complete cure in three patients and in a reduction of tumor mass in three. Twenty-one (70%) of the patients died of thyroid cancer after a mean survival of 86 months. Of the nine patients still alive, two aremore » free of disease, three have a good quality of life, and four have severe disability.« less

Authors:
; ; ; ; ; ; ;  [1]
  1. Univ. of Pisa (Italy)
Publication Date:
OSTI Identifier:
5028215
Resource Type:
Journal Article
Journal Name:
Surgery; (USA)
Additional Journal Information:
Journal Volume: 106:6; Journal ID: ISSN 0039-6060
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; RADIOBIOLOGY; SKELETON; METASTASES; THYROID; BIOMEDICAL RADIOGRAPHY; DIAGNOSIS; IODINE 131; RADIOISOTOPE SCANNING; RADIOTHERAPY; SURVIVAL CURVES; THYROIDECTOMY; THYROXINE; X RADIATION; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGY; BODY; CARBOXYLIC ACIDS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTROMAGNETIC RADIATION; ENDOCRINE GLANDS; GLANDS; HORMONES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; IONIZING RADIATIONS; ISOTOPES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; PEPTIDE HORMONES; RADIATIONS; RADIOISOTOPES; RADIOLOGY; SURGERY; THERAPY; THYROID HORMONES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550602 - Medicine- External Radiation in Diagnostics- (1980-); 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-); 550600 - Medicine

Citation Formats

Marcocci, C, Pacini, F, Elisei, R, Schipani, E, Ceccarelli, C, Miccoli, P, Arganini, M, and Pinchera, A. Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma. United States: N. p., 1989. Web.
Marcocci, C, Pacini, F, Elisei, R, Schipani, E, Ceccarelli, C, Miccoli, P, Arganini, M, & Pinchera, A. Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma. United States.
Marcocci, C, Pacini, F, Elisei, R, Schipani, E, Ceccarelli, C, Miccoli, P, Arganini, M, and Pinchera, A. 1989. "Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma". United States.
@article{osti_5028215,
title = {Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma},
author = {Marcocci, C and Pacini, F and Elisei, R and Schipani, E and Ceccarelli, C and Miccoli, P and Arganini, M and Pinchera, A},
abstractNote = {Thirty (3.8%) of 780 patients with differentiated thyroid cancer seen between 1970 and 1987 had bone metastases. The primary tumor was follicular in 26 patients and papillary in four. Mean age at diagnosis was 61 years. The manifestation of bone metastases was the presenting symptom in 18 patients (60%). Treatment included total thyroidectomy, levothyroxine sodium therapy, and radioactive iodine treatments. Twenty-seven patients had bone metastases from the initial observation, with 44 sites involved. Of the sites, 27 (61%) were shown both on iodine 131 whole-body scan (WBS) and on x-ray film, 11 (25%) only on WBS, and six (14%) only on x-ray film. Multiple involvement was observed in 11 patients. The radiologic appearance was invariably osteolytic. Serum thyroglobulin was elevated in all patients. After radioactive iodine, no WBS+/X-ray+ metastases showed a complete response, although a sclerotic border was noted in several cases, whereas six WBS+/X-ray- lesions were no longer detectable by WBS. Treatment with radioactive iodine and bone surgery resulted in a complete cure in three patients and in a reduction of tumor mass in three. Twenty-one (70%) of the patients died of thyroid cancer after a mean survival of 86 months. Of the nine patients still alive, two are free of disease, three have a good quality of life, and four have severe disability.},
doi = {},
url = {https://www.osti.gov/biblio/5028215}, journal = {Surgery; (USA)},
issn = {0039-6060},
number = ,
volume = 106:6,
place = {United States},
year = {Fri Dec 01 00:00:00 EST 1989},
month = {Fri Dec 01 00:00:00 EST 1989}
}