Antibody guided diagnosis and therapy of brain gliomas using radiolabeled monoclonal antibodies against epidermal growth factor receptor and placental alkaline phosphatase

Journal Article · Sun Oct 01 00:00:00 EDT 1989 · Journal of Nuclear Medicine; (USA)

OSTI ID:5028096

Kalofonos, H P; Pawlikowska, T R; Hemingway, A; Courtenay-Luck, N; Dhokia, B; Snook, D; Sivolapenko, G B; Hooker, G R; McKenzie, C G; Lavender, P J ^[1]

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1. Royal Postgraduate Medical School, London (England)

Twenty-seven patients with brain glioma were scanned using {sup 123}I-labeled monoclonal antibodies against epidermal growth factor receptor (EGFR1) or placental alkaline phosphatase (H17E2). Successful localization was achieved in 18 out of 27 patients. Eleven out of 27 patients were also studied using a nonspecific control antibody (11.4.1) of the same immunoglobulin subclass and observable tumor localization was also achieved in five patients. The specificity of targeting was assessed by comparing images obtained with specific and nonspecific antibodies and by examining tumor and normal tissue biopsies after dual antibody administration. Ten patients with recurrent grade III or IV glioma who showed good localization of radiolabeled antibody were treated with 40-140 mCi of {sup 131}I-labeled antibody delivered to the tumor area intravenously (n = 5) or by infusion into the internal carotid artery (n = 5). Six patients showed clinical improvement lasting from 6 mo to 3 yr. One patient continues in remission (3 yr after therapy), but the other five who responded initially relapsed 6-9 mo after therapy and died. No major toxicity was attributable to antibody-guided irradiation. Targeted irradiation by monoclonal antibody may be clinically useful and should be explored further in the treatment of brain gliomas resistant to conventional forms of treatment.

• OSTI ID: 5028096
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 30:10; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GLIOMAS
DIAGNOSIS
RADIOIMMUNOTHERAPY
GROWTH FACTORS
RECEPTORS
MONOCLONAL ANTIBODIES
SPECIFICITY
ALKALINE PHOSPHATASE
BRAIN
IODINE 123
IODINE 131
PATIENTS
PLACENTA
PREGNANCY
RADIOIMMUNOSCINTIGRAPHY
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
ESTERASES
FETAL MEMBRANES
HOURS LIVING RADIOISOTOPES
HYDROLASES
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MEDICINE
MEMBRANE PROTEINS
MEMBRANES
MITOGENS
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHOSPHATASES
PROTEINS
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SCINTISCANNING
THERAPY
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)