Biological variability model of cell survival curves

Journal Article · Sun Jun 01 00:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575326· OSTI ID:5025351

Domon, M

The radiation sensitivity of a mammalian cell population has been conventionally characterized by the survival curve parameters, n and D/sub 0/. The present correspondence concerns the interpretation of these parameters when there is biological variability in the radiation sensitivity of a cell population. To derive a relationship between the survival curve parameters and the biological variability, a log-normal distribution was assumed for the sensitivity variability. For a given spread of the distribution, a survival curve on a semilogarithmic scale was obtained graphically. Analysis of such survival curves led to the conclusion that n is inversely related to the spread and the D/sub 0/ is determined by both the LD/sub 50/ and the spread of the log-normal distribution.

• Research Organization: Tokyo Medical and Dental Univ., Japan
• OSTI ID: 5025351
• Journal Information: Radiat. Res.; (United States), Vol. 82:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
RADIOSENSITIVITY
SURVIVAL CURVES
BIOLOGICAL VARIABILITY
BIOLOGICAL MODELS
CELL KILLING
DOSE-RESPONSE RELATIONSHIPS
RADIATION DOSES
DOSES
560121* - Radiation Effects on Cells- External Source- (-1987)