Radio-protective effect of sodium meclofenamate. A prospective clinical trial

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Journal of Medicine (Westbury, New York); (USA)

OSTI ID:5024909

Mahafzah, M; Halpern, J; Nava, H R; Huben, R P; Sayyid, S; Bryson, W; Ambrus, J L ^[1]

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1. Sisters of Charity Hospital, Buffalo, NY (USA)

Twentyfour patients treated with irradiation to either their pelvis or their chest for neoplastic disease were included in a randomized study of radioprotection with sodium meclofenamate (Meclomen) (SM). Seventeen patients received SM 100 mg, p.os, t.i.d., and seven received placebo. The long-range radiation related chronic gastrointestinal and urinary tract toxicity was diminished by SM. At 12 months post irradiation, SM treated patients experienced less gastrointestinal and urinary symptoms, as well as less measured bladder contraction, than the controls. Acute gastrointestinal signs of radiotoxicity, however, seemed to have been enhanced by SM. The treated patients suffered from nausea, vomiting, and diarrhea. These acute toxic effects were temporary and reversible.

• OSTI ID: 5024909
• Journal Information: Journal of Medicine (Westbury, New York); (USA), Vol. 20:3-4; ISSN 0025-7850
• Country of Publication: United States
• Language: English

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