Primary lung cancer: Biodistribution and dosimetry of two In-111-labeled monoclonal antibodies
- Veterans Administration Medical Center, Portland, OR (USA)
This study was undertaken to measure the biokinetics and organ dosimetry of indium-111-labeled monoclonal antibodies (MoAbs) with a whole-body gamma camera imaging technique. Twenty patients with primary lung cancer were studied with two different MoAb agents (anti-carcinoembryonic antigen ZCEO25 and antiadenocarcinoma LA20207). Imaging was performed at 1, 24, 72, and 144 hours after injection. Scintigraphic whole-body retention was verified by means of comparison with the results from in vitro counting of excreta. Organ retention was verified in an abdominal phantom. The MoAb cleared slowly from the heart and lungs, the brain and spleen showed no clearance, and the liver showed increased activity over the 6-day period. Dosimetry for ZCE025 showed a dose to the liver of 1.3 rad/mCi (0.36 mGy/MBq); heart, 1.5 rad/mCi (0.40 mGy/MBq); spleen, 1.1 rad/mCi (0.29 mGy/MBq); total body, 0.49 rad/mCi (0.13 mGy/MBq); and testes, 0.39 rad/mCi (0.11 mGy/MBq). The dosimetry for LA20207 was similar.
- OSTI ID:
- 5024853
- Journal Information:
- Radiology; (USA), Vol. 173:3; ISSN 0033-8419
- Country of Publication:
- United States
- Language:
- English
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LUNGS
NEOPLASMS
MONOCLONAL ANTIBODIES
TISSUE DISTRIBUTION
DIAGNOSIS
CARCINOEMBRYONIC ANTIGEN
INDIUM 111
RADIATION DOSES
RADIOIMMUNOSCINTIGRAPHY
SPECIFICITY
WHOLE-BODY COUNTING
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DOSES
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics