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Title: Neonatal developmental pattern of superoxide dismutase and aniline hydroxylase in rat lung

Abstract

The developmental biology of superoxide dismutase and aniline hydroxylase was followed in rat lungs from prenatal stage to 3 months old. Total superoxide dismutase activity as determined by spectrophotometry as well as electrophoresis was high in the prenatal rat lung, decreased in the first 24 hr postpartum, increased within 7 days, and then decreased gradually to adult levels. On polyacrylamide gel electrophoresis only two isozymic forms of superoxide dismutase were located as achromatic zones in the fetal lung. In the adult rat lung, there were three molecular forms of superoxide dismutase, two in the postmitochondrial supernatant and one in the mitochondrial fraction. Unlike superoxide dismutase, aniline hydroxylase was detectable only after 5 days of age and the activity exhibited a gradual increase afterward up to 1 month of age. The developmental pattern of superoxide dismutase and aniline hydroxylase activities in lung may be significant in understanding the mechanism of body defenses and their regulatory modulations in response to toxic air pollutants and environmental stress.

Authors:
; ;
Publication Date:
Research Org.:
Industrial Toxicology Research Centre, Lucknow, India
OSTI Identifier:
5023541
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 41:1
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ENZYME ACTIVITY; ONTOGENESIS; HYDROXYLASES; LUNGS; SUPEROXIDE DISMUTASE; AGE DEPENDENCE; AIR POLLUTION; EXPERIMENTAL DATA; IMMUNITY; NEONATES; POLLUTANTS; RATS; ANIMALS; BODY; DATA; ENZYMES; INFORMATION; MAMMALS; NUMERICAL DATA; ORGANS; OXIDOREDUCTASES; POLLUTION; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; 550200* - Biochemistry; 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Kakkar, P, Jaffery, F N, and Viswanathan, P N. Neonatal developmental pattern of superoxide dismutase and aniline hydroxylase in rat lung. United States: N. p., 1986. Web. doi:10.1016/S0013-9351(86)80191-8.
Kakkar, P, Jaffery, F N, & Viswanathan, P N. Neonatal developmental pattern of superoxide dismutase and aniline hydroxylase in rat lung. United States. https://doi.org/10.1016/S0013-9351(86)80191-8
Kakkar, P, Jaffery, F N, and Viswanathan, P N. 1986. "Neonatal developmental pattern of superoxide dismutase and aniline hydroxylase in rat lung". United States. https://doi.org/10.1016/S0013-9351(86)80191-8.
@article{osti_5023541,
title = {Neonatal developmental pattern of superoxide dismutase and aniline hydroxylase in rat lung},
author = {Kakkar, P and Jaffery, F N and Viswanathan, P N},
abstractNote = {The developmental biology of superoxide dismutase and aniline hydroxylase was followed in rat lungs from prenatal stage to 3 months old. Total superoxide dismutase activity as determined by spectrophotometry as well as electrophoresis was high in the prenatal rat lung, decreased in the first 24 hr postpartum, increased within 7 days, and then decreased gradually to adult levels. On polyacrylamide gel electrophoresis only two isozymic forms of superoxide dismutase were located as achromatic zones in the fetal lung. In the adult rat lung, there were three molecular forms of superoxide dismutase, two in the postmitochondrial supernatant and one in the mitochondrial fraction. Unlike superoxide dismutase, aniline hydroxylase was detectable only after 5 days of age and the activity exhibited a gradual increase afterward up to 1 month of age. The developmental pattern of superoxide dismutase and aniline hydroxylase activities in lung may be significant in understanding the mechanism of body defenses and their regulatory modulations in response to toxic air pollutants and environmental stress.},
doi = {10.1016/S0013-9351(86)80191-8},
url = {https://www.osti.gov/biblio/5023541}, journal = {Environ. Res.; (United States)},
number = ,
volume = 41:1,
place = {United States},
year = {Wed Oct 01 00:00:00 EDT 1986},
month = {Wed Oct 01 00:00:00 EDT 1986}
}