Antibody-dependent cellular cytotoxicity and skin disease

Journal Article · Mon Jul 01 00:00:00 EDT 1985 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12276370· OSTI ID:5021917

Norris, D A; Lee, L A

Antibody dependent cellular cytotoxicity (ADCC) is a recently described mechanism of immunologic lysis in which cellular targets sensitized by specific antibodies are efficiently and selectively lysed by Fc receptor (FcR) bearing nonspecific effectors. Immunoglobulins of various classes (IgG, IgM, IgA, IgE) and various cellular effectors (large granular lymphocytes, monocyte/macrophages, T lymphocytes, neutrophils, and eosinophils) can induce ADCC in vitro, and the importance of ADCC in vivo is being tested experimentally in resistance to viral, bacterial, and parasitic infection, in tumor surveillance, in allograft rejection, and in inflammatory diseases. There is much indirect evidence that ADCC may be the mechanism of damage of different cellular targets in skin diseases, but the best direct evidence concerns immunologic keratinocyte damage, especially in cutaneous lupus erythematosus (LE). The authors have shown that keratinocytes of several species are highly susceptible to lymphocyte and monocyte-mediated ADCC, but not to neutrophil or eosinophil ADCC in vitro using two different cytotoxicity assays. In contrast, complement was a relatively ineffective mediator of lysis of metabolically intact keratinocyte targets. Patients with certain cutaneous lupus syndromes have serum antibodies capable of inducing monocyte and lymphocyte ADCC of targets coated with extractable nuclear antigens. The authors have shown that these antigens apparently move to the cell membrane of keratinocytes in vitro following ultraviolet irradiation. In an animal model, they have shown that antibodies to SSA/Ro bind to human keratinocytes in vivo, especially after ultraviolet irradiation.

• Research Organization: Univ. of Colorado Health Sciences Center, Denver
• OSTI ID: 5021917
• Journal Information: J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
MONOCYTES
BIOLOGICAL RADIATION EFFECTS
PATIENTS
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL MODELS
COMPLEMENT
IMMUNOGLOBULINS
KERATIN
LYMPHOCYTES
MACROPHAGES
MICE
NEUTROPHILS
RECEPTORS
SKIN DISEASES
ULTRAVIOLET RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
GLOBULINS
LEUKOCYTES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
PHAGOCYTES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SCLEROPROTEINS
SOMATIC CELLS
VERTEBRATES
550101* - Behavioral Biology- Tracer Techniques
550901 - Pathology- Tracer Techniques