Transient, heat-induced thermal resistance in the small intestine of mouse

Journal Article · Sun Jun 01 00:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575319· OSTI ID:5021543

Hume, S P; Marigold, J C.L.

Heat-induced thermal resistance has been investigated in mouse jejunum by assaying crypt survival 24 h after treatment. Hyperthermia was achieved by immersing an exteriorized loop of intestine in a bath of Krebs-Ringer solution. Two approaches have been used. In the first, thermal survival curves were obtained following single hyperthermal treatments at temperatures in the range 42 to 44/sup 0/C. Transient thermal resistance, inducted by a plateau in the crypt survival curve, developed during heating at temperatures around 42.5/sup 0/C after 60 to 80 min. In the second series of experiments, a priming heat treatment (40.0, 41.0, 41.5, or 42.0/sup 0/C for 60 min) was followed at varying intervals by a test treatment at 43.0/sup 0/C. A transient resistance to the second treatment was induced, the extent and time of development being dependent upon the priming treatment. Crypt survival curves for thermally resistant intestine showed an increase in thermal D/sub 0/ and a decrease in n compared with curves from previously unheated intestine.

• Research Organization: Hammersmith Hospital, London, England
• OSTI ID: 5021543
• Journal Information: Radiat. Res.; (United States), Vol. 82:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
CRYPT CELLS
TOLERANCE
HEAT
BIOLOGICAL EFFECTS
HYPERTHERMIA
RADIOSENSITIVITY EFFECTS
MICE
SMALL INTESTINE
SURVIVAL CURVES
ANIMAL CELLS
ANIMALS
BODY
BODY TEMPERATURE
DIGESTIVE SYSTEM
ENERGY
GASTROINTESTINAL TRACT
INTESTINES
MAMMALS
ORGANS
RODENTS
SOMATIC CELLS
VERTEBRATES
560400* - Other Environmental Pollutant Effects
550603 - Medicine- External Radiation in Therapy- (1980-)