Dose of house dust mite antigen (P1) inhaled by infants aged one month
A survey of the habitats occupied by 12 infants of one month of age revealed that approximately 10% of their day was spent in conditions of potential exposure to the major (P1) allergen of the house dust mite, Dermatophagoides pteronyssinus. A respiratory pump which reproduced the minute ventilation of an infant was placed in representative infant habitats. The P1 allergen trapped by the filter in this pump was measured as an estimate of infants' allergen intake. Detectable P1 intake was only present when there was active air disturbance (bed making and vacuuming). The average P1 intake was approximately 3 ng P1/24 hours. Comparison of this P1 intake with that which sensitizes in other situations suggests that it is usually inadequate to sensitize infants.
- Research Organization:
- Univ. of Bristol, England
- OSTI ID:
- 5020312
- Journal Information:
- Ann. Allergy; (United States), Vol. 51:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANTIGENS
INHALATION
INFANTS
IMMUNOLOGY
ALLERGY
DOSE-RESPONSE RELATIONSHIPS
DUSTS
FILTERS
MITES
RESIDENTIAL BUILDINGS
AGE GROUPS
ANIMALS
ARACHNIDS
ARTHROPODS
BUILDINGS
CHILDREN
INTAKE
INVERTEBRATES
PATHOLOGICAL CHANGES
551000* - Physiological Systems
550700 - Microbiology