Physical and genetic localization of the gene encoding the AP-2 transcription factor to mouse chromosome 13
- Yale Univ., New Haven, CT (United States)
- Jefferson Cancer Institute, Philadelphia, PA (United States); and others
Transcription factors are a major determinant of developmental fate. The chromosomal localization of the genes encoding these proteins provides important information that can link them to known genetic abnormalities. Here, we report the mapping of the mouse gene for transcription factor AP-2, a protein that has been implicated in human oncogenesis. Using FISH, we have mapped the gene encoding the transcription factor AP-2, Tcfap2, to mouse Chromosome 13A5-B1. We have also extended this analysis by placing Tcfap2 on the mouse mutations that map in the vicinity of this transcription factor. 25 refs., 2 figs., 1 tab.
- OSTI ID:
- 501822
- Journal Information:
- Genomics, Vol. 31, Issue 2; Other Information: PBD: 15 Jan 1996
- Country of Publication:
- United States
- Language:
- English
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