Comparison of Tc-99m labeled liver and liver pate as markers for solid-phase gastric emptying
A radionuclide marker for studies of solid-phase gastric emptying should have a high labeling efficiency and remain relatively stable during gastric emptying. The availability of materials and the ease of preparation are also considerations in selecting radionuclide markers. The stability of intracellularly labeled chicken liver, surface-labeled chicken liver, and labeled pureed meat (liver pate) incubated with hydrochloric acid solution or gastric juice have been compared. Intracellularly labeled chicken liver and labeled liver pate were also compared in gastric emptying studies in humans. In vitro results demonstrated labeling efficiencies greater than 92% for both intracellularly labeled liver and labeled liver pate. The pate labeled with Tc-99m sulfur colloid was more stable than Tc-99m surface-labeled liver in vitro and its prepartion was easier than with the intracellular labeling technique. Gastric emptying studies on normal subjects demonstrated equal performance of the intracellularly labeled liver and the labeled liver pate. Labeled liver pate is thus an alternative to intracellularly labeled chicken liver in measuring solid-phase gastric emptying.
- Research Organization:
- Univ. of Utah Medical Center, Salt Lake City
- OSTI ID:
- 5014134
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:3
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
STOMACH
RETENTION FUNCTIONS
SCINTISCANNING
TECHNETIUM 99
CHICKENS
GASTRIC ACID
HYDROCHLORIC ACID
ISOMERIC NUCLEI
LIVER
MEN
RADIOCOLLOIDS
SULFUR COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIRDS
BODY
BODY FLUIDS
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISPERSIONS
FOWL
FUNCTIONS
GASTROINTESTINAL TRACT
GLANDS
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INORGANIC ACIDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MALES
MAMMALS
MAN
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques