Neurobiological actions of cysteamine

Journal Article · Sat Jun 01 00:00:00 EDT 1985 · Fed. Proc.; (United States)

OSTI ID:5013730

Brown, M; Fisher, L; Mason, R T; Rivier, J; Vale, W

Somatostatin (SS)-related peptides act within discrete brain regions to inhibit adrenal epinephrine (E) secretion, to prevent hypothermia, and to produce hyperthermia. Depletion of brain concentrations of these SS-related peptides using cysteamine (CSH) or central administration of an SS receptor antagonist increases adrenal E secretion and impairs thermoregulation. These actions of CSH and the SS receptor antagonist are reversed by administration of SS into the central nervous system. These results support the hypothesis that endogenous brain SS-related peptides are involved in the regulation of adrenal E secretion and thermoregulation.

• OSTI ID: 5013730
• Journal Information: Fed. Proc.; (United States), Vol. 9
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CYSTAMINE
BIOLOGICAL EFFECTS
PEPTIDES
BIOLOGICAL FUNCTIONS
ADRENALINE
BLOOD CHEMISTRY
BRAIN
NEUROREGULATORS
PROSTAGLANDINS
RATS
RECEPTORS
SOMATOSTATIN
ADRENAL HORMONES
AMINES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DRUGS
FUNCTIONS
HORMONES
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)