Brief inhalation method to measure cerebral oxygen extraction fraction with PET: Accuracy determination under pathologic conditions

Journal Article · Sun Sep 01 00:00:00 EDT 1991 · Journal of Nuclear Medicine; (United States)

OSTI ID:5013330

Altman, D I; Lich, L L; Powers, W J ^[1]

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1. Division of Radiation Sciences, Mallinckrodt Institute of Radiology, St. Louis, MO (United States)

The initial validation of the brief inhalation method to measure cerebral oxygen extraction fraction (OEF) with positron emission tomography (PET) was performed in non-human primates with predominantly normal cerebral oxygen metabolism (CMRO2). Sensitivity analysis by computer simulation, however, indicated that this method may be subject to increasing error as CMRO2 decreases. Accuracy of the method under pathologic conditions of reduced CMRO2 has not been determined. Since reduced CMRO2 values are observed frequently in newborn infants and in regions of ischemia and infarction in adults, we determined the accuracy of the brief inhalation method in non-human primates by comparing OEF measured with PET to OEF measured by arteriovenous oxygen difference (A-VO2) under pathologic conditions of reduced CMRO2 (0.27-2.68 ml 100g-1 min-1). A regression equation of OEF (PET) = 1.07 {times} OEF (A-VO2) + 0.017 (r = 0.99, n = 12) was obtained. The absolute error in oxygen extraction measured with PET was small (mean 0.03 {plus minus} 0.04, range -0.03 to 0.12) and was independent of cerebral blood flow, cerebral blood volume, CMRO2, or OEF. The percent error was higher (19 {plus minus} 37), particularly when OEF is below 0.15. These data indicate that the brief inhalation method can be used for measurement of cerebral oxygen extraction and cerebral oxygen metabolism under pathologic conditions of reduced cerebral oxygen metabolism, with these limitations borne in mind.

• OSTI ID: 5013330
• Journal Information: Journal of Nuclear Medicine; (United States), Vol. 32:9; ISSN 0161-5505
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
CEREBRAL CORTEX
BLOOD FLOW
OXYGEN
METABOLISM
POSITRON COMPUTED TOMOGRAPHY
SENSITIVITY ANALYSIS
VASCULAR DISEASES
DIAGNOSIS
ACCURACY
BRAIN
COMPUTERIZED SIMULATION
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ANIMALS
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MAMMALS
MATHEMATICS
MONKEYS
NERVOUS SYSTEM
NONMETALS
ORGANS
PRIMATES
SIMULATION
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550601* - Medicine- Unsealed Radionuclides in Diagnostics