Oncogenic action of ionizing radiation on rat skin. Progress report, February 1, 1985-January 31, 1986

Technical Report · Wed Jan 01 00:00:00 EST 1986

OSTI ID:5012063

Burns, F J

The track model is based on the general ideas inherent in quadratic theory of carcinogenesis, namely that two critical, dose-dependent events are necessary to start a cell on its progression to cancer. Other non-dose-dependent events may be involved in later stages. Later events probably occur in association with cell division so that the initial DNA damage is converted to a form that is transmissible. The model being developed here is based on the idea that the geometrical distribution of the initial lesions within the target cell is critical to the biological alteration that predisposes the cells to carcinogenesis. Experiments performed which exposed rat skin to ionizing radiation are described with reference to the above model. 33 refs. (DT)

• Research Organization: New York Univ., NY (USA). Dept. of Environmental Medicine
• DOE Contract Number: AC02-76EV03380
• OSTI ID: 5012063
• Report Number(s): DOE/EV/03380-41; ON: DE86002053
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DNA REPAIR
AGE DEPENDENCE
ONCOGENIC TRANSFORMATIONS
RADIOINDUCTION
TIME DEPENDENCE
SKIN
STRAND BREAKS
DOSE-RESPONSE RELATIONSHIPS
VITAMIN A
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
DIMETHYLBENZANTHRACENE
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
LET
MICE
RADIOBIOLOGY
RATS
THYMINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
AROMATICS
AZINES
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOLOGY
BODY
CELL TRANSFORMATIONS
CONDENSED AROMATICS
ENERGY TRANSFER
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IRRADIATION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIATIONS
RECOVERY
REPAIR
RODENTS
URACILS
VERTEBRATES
VITAMINS
560152* - Radiation Effects on Animals- Animals
560114 - Radiation Effects on Biochemicals- In Animals- (-1987)