Thymic irradiation inhibits the rapid recovery of TH1 but not TH2-like functions of CD4+ T cells after total lymphoid irradiation
- Department of Medicine, Stanford University School of Medicine, CA (United States)
Four to six weeks after total lymphoid irradiation (TLI), there is a selective deficit in the CD4+ T cells which secrete IL-2, proliferate in the MLR, and induce GVHD (Th1-like functions). A similar deficit in CD4+ T cells which secrete IL-4 and help antibody responses (Th2-like functions) is not observed. In the present study, shielding of the thymus with lead during TLI increased the Th1-like functions of CD4+ cells. Mice without thymus shields showed a marked selective reduction in the medullary stromal cells identified with the monoclonal antibody, MD1, and the severe reduction was prevented with thymus shields. Thus, shielding the thymus prevents the depletion of thymic medullary stromal cells and allows for a rapid recovery of Th1-like functions in the mouse spleen after TLI. Th2-like functions recover rapidly after TLI whether or not the thymus is irradiated.
- OSTI ID:
- 5011403
- Journal Information:
- Cellular Immunology; (United States), Vol. 137:2; ISSN 0008-8749
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LYMPHATIC SYSTEM
IRRADIATION
LYMPHOCYTES
CELL PROLIFERATION
LYMPHOKINES
SECRETION
THYMUS
BIOLOGICAL RADIATION EFFECTS
ANTIBODY FORMATION
BIOLOGICAL SHIELDING
GRAFT-HOST REACTION
IMMUNITY
IMMUNOGLOBULINS
INHIBITION
MICE
MONOCLONAL ANTIBODIES
SPLEEN
WHOLE-BODY IRRADIATION
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
EXTERNAL IRRADIATION
GLOBULINS
GROWTH FACTORS
LEUKOCYTES
MAMMALS
MATERIALS
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RODENTS
SHIELDING
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals