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Title: The effects of early postoperative radiation on vascularized bone grafts

Abstract

The effects of early postoperative radiation were assessed in free nonvascularized and free vascularized rib grafts in the canine model. The mandibles of one-half of the dogs were exposed to a cobalt 60 radiation dose of 4080 cGy over a 4-week period, starting 2 weeks postoperatively. The patency of vascularized grafts was confirmed with bone scintigraphy. Histological studies, including ultraviolet microscopy with trifluorochrome labeling, and histomorphometric analyses were performed. Osteocytes persist within the cortex of the vascularized nonradiated grafts to a much greater extent than in nonvascularized, nonradiated grafts. Cortical osteocytes do not persist in either vascularized or nonvascularized grafts subjected to radiation. New bone formation is significantly retarded in radiated grafts compared with nonradiated grafts. Periosteum and endosteum remained viable in the radiated vascularized grafts, producing both bone union and increased bone turnover, neither of which were evident to any significant extent in nonvascularized grafts. Bone union was achieved in vascularized and non-vascularized nonradiated bone. In the radiated group of dogs, union was only seen in the vascularized bone grafts.

Authors:
; ;  [1]
  1. Division of Plastic and Reconstructive Surgery, University of Western Ontario, London (Canada)
Publication Date:
OSTI Identifier:
5011382
Resource Type:
Journal Article
Journal Name:
Annals of Plastic Surgery; (United States)
Additional Journal Information:
Journal Volume: 26:6; Journal ID: ISSN 0148-7043
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE CELLS; BIOLOGICAL RADIATION EFFECTS; SKELETON; GRAFTS; COBALT 60; DOGS; RADIATION DOSES; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; DOSES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIATION EFFECTS; RADIOISOTOPES; SOMATIC CELLS; TRANSPLANTS; VERTEBRATES; YEARS LIVING RADIOISOT; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Evans, H B, Brown, S, and Hurst, L N. The effects of early postoperative radiation on vascularized bone grafts. United States: N. p., 1991. Web. doi:10.1097/00000637-199106000-00002.
Evans, H B, Brown, S, & Hurst, L N. The effects of early postoperative radiation on vascularized bone grafts. United States. https://doi.org/10.1097/00000637-199106000-00002
Evans, H B, Brown, S, and Hurst, L N. 1991. "The effects of early postoperative radiation on vascularized bone grafts". United States. https://doi.org/10.1097/00000637-199106000-00002.
@article{osti_5011382,
title = {The effects of early postoperative radiation on vascularized bone grafts},
author = {Evans, H B and Brown, S and Hurst, L N},
abstractNote = {The effects of early postoperative radiation were assessed in free nonvascularized and free vascularized rib grafts in the canine model. The mandibles of one-half of the dogs were exposed to a cobalt 60 radiation dose of 4080 cGy over a 4-week period, starting 2 weeks postoperatively. The patency of vascularized grafts was confirmed with bone scintigraphy. Histological studies, including ultraviolet microscopy with trifluorochrome labeling, and histomorphometric analyses were performed. Osteocytes persist within the cortex of the vascularized nonradiated grafts to a much greater extent than in nonvascularized, nonradiated grafts. Cortical osteocytes do not persist in either vascularized or nonvascularized grafts subjected to radiation. New bone formation is significantly retarded in radiated grafts compared with nonradiated grafts. Periosteum and endosteum remained viable in the radiated vascularized grafts, producing both bone union and increased bone turnover, neither of which were evident to any significant extent in nonvascularized grafts. Bone union was achieved in vascularized and non-vascularized nonradiated bone. In the radiated group of dogs, union was only seen in the vascularized bone grafts.},
doi = {10.1097/00000637-199106000-00002},
url = {https://www.osti.gov/biblio/5011382}, journal = {Annals of Plastic Surgery; (United States)},
issn = {0148-7043},
number = ,
volume = 26:6,
place = {United States},
year = {Sat Jun 01 00:00:00 EDT 1991},
month = {Sat Jun 01 00:00:00 EDT 1991}
}