Phylogenetic distribution of (/sup 3/H)cyclohexyladenosine binding sites in nervous tissue

Journal Article · Thu May 29 00:00:00 EDT 1986 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(86)91193-9· OSTI ID:5009152

Siebenaller, J F; Murray, T F

The specific binding of the A/sub 1/ adenosine receptor ligand. (/sup 3/H)CHA, was investigated in membrane fractions prepared from brains of eleven vertebrate species and ganglia of four invertebrate species. Substantial amounts of specific (/sup 3/H)CHA binding sites were demonstrated in brain membranes of all vertebrate species examined; however, (/sup 3/H)CHA binding sites were not detectable in nervous sites in vertebrate brains increase in higher vertebrates. Moreover, the pharmacological characteristics of the site labeled by (/sup 3/H)CHA in two divergent classes of vertebrates were similar. The broad phylogenetic distribution of A/sub 1/ adenosine receptors in primitive as well as advanced vertebrate species suggests a fundamental role for adenosine in neuronal modulation.

• Research Organization: Louisiana State Univ., Baton Rouge
• OSTI ID: 5009152
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Vol. 137:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ADENOSINE
BIOCHEMICAL REACTION KINETICS
RADIORECEPTOR ASSAY
BRAIN
GANGLIONS
INVERTEBRATES
LIGANDS
NERVE CELLS
RECEPTORS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
ANIMAL CELLS
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
DISTRIBUTION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REACTION KINETICS
RIBOSIDES
SOMATIC CELLS
550201* - Biochemistry- Tracer Techniques