Abnormal expression of the calmodulin gene in muscle from the dystrophic chicken

Journal Article · Thu May 29 00:00:00 EDT 1986 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(86)91239-8· OSTI ID:5008687

Hudecki, M S; Kibler, P K; Pollina, C M; Thacore, H R; Davis, P J; Davis, F B

Compared to that of genetically-related normal chickens, pectoralis muscle from the dystrophic chicken contained increased calmodulin measured by radioimmunoassay. Determined by the dot blot procedure, expression of the calmodulin gene was enhanced in muscle from affected animals. The bioactivity of the gene product was normal. Together with previous studies reporting of increased sarcoplasmic calmodulin suggest the latter is a cellular response to defective Ca/sup 2 +/ transport at the level of cell efflux or intracellular organelle (sarcoplasmic reticulum) uptake.

• Research Organization: State Univ. of New York, Buffalo
• OSTI ID: 5008687
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Vol. 137:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DISEASES
PATHOGENESIS
PROTEINS
RADIOIMMUNOASSAY
CALCIUM COMPOUNDS
CATIONS
CELL FLOW SYSTEMS
CHICKENS
EXPERIMENTAL DATA
GENE REGULATION
MUSCLES
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550401* - Genetics- Tracer Techniques